Antoine Griezmann rescued a 1-1 draw for Barcelona at Napoli in the first leg of their Champions League last-16 tie on Tuesday.
Frenchman Griezmann struck just before the hour mark in Naples after Dries Mertens had put the hosts ahead in the 30th minute with his 121st Napoli goal, drawing level with Marek Hamsik as the club’s all-time top scorer.
Barcelona ended the game with 10 men after Arturo Vidal was sent off with two minutes to go after picking up two yellow cards, following an angry clash with Napoli defender Mario Rui.
The clash was the first between the two teams and also a Champions League debut for both Setien and Napoli counterpart Gennaro Gattuso, who took over after the group stage.
Lionel Messi failed to score on his first appearance at the Stadio San Paolo, where Napoli legend Diego Maradona reigned supreme three decades ago.
Elsewhere, Serge Gnabry fired Bayern Munich to the brink of the quarterfinals as the German’s double inspired a superb 3-0 rout of Chelsea in the last-16 first leg at Stamford Bridge on Tuesday.
Gnabry had tormented Tottenham Hotspur with four goals in Bayern’s 7-2 victory in north London earlier this season and the former Arsenal winger returned to the English capital to push Chelsea to the brink of elimination.
His two goals in the space of three minutes left Hansi Flick’s side within touching distance of the last eight.
Robert Lewandowski got Bayern’s third before Chelsea defender Marcos Alonso was sent off in the 83rd minute.
Chelsea will need another Munich miracle in the second leg on March 18 to overturn the deficit at the Allianz Arena, where they famously beat the German club in the 2012 Champions League final.