A Ukrainian Boeing 737 plane carrying 180 passengers on board crashed near Tehran International Airport, Iran, in the early hours of Wednesday shortly after take off, killing all 180 people on board.
While it is not immediately clear what caused the crash, Iranian local news media has attributed it to a technical fault.
Iran’s Red Crescent said there is no chance of finding survivors.
The aircraft belonging to Ukraine International Airlines crashed just after take-off from Iran’s Imam Khomeini airport in Tehran, said the Fars state news agency.
Preliminary reports suggest that the plane was en route to the Ukrainian capital of Kyiv.
Rescue teams have been sent to the area, near the airport, where the aircraft crashed.
The head of Iran’s Red Crescent told state media that it was “impossible” for anyone to have survived the crash.
Ukrainian President Volodymyr Zelensky said efforts were being made to establish the circumstances of the crash and the death toll.
“My sincere condolences to the relatives and friends of all passengers and crew,” he said in a statement.
Mr Zelensky was cutting short a visit to Oman and returning to Kyiv, the statement said.
It is unclear whether the incident is linked to the Iran-US confrontation.